Which of the following is a requirement before sterilizing instruments?

Before sterilizing instruments, it is crucial that they are thoroughly cleaned to remove any organic matter, debris, or contaminants. This cleaning process often involves brushing or swabbing the instruments to ensure that all surfaces are free from residues that could impede effective sterilization. If instruments are not properly cleaned beforehand, the sterilization process may be compromised, leading to a risk of infection.

The other options do not correctly represent requirements for sterilizing instruments. Leaving instruments dirty would increase the risk of infection, while running them under high pressure or heating them does not effectively clean them prior to sterilization. Effective sterilization is contingent on the cleanliness of the instruments, making brushing or swabbing an essential step in the process.